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Plant “Polyphenolic” Small Molecules Can Induce a Calorie Restriction‐Mimetic Life‐Span Extension by Activating Sirtuins: Will “Polyphenols” Someday Be Used as Chemotherapeutic Drugs in Western Medicine?
Author(s) -
Quideau Stéphane
Publication year - 2004
Publication title -
chembiochem
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.05
H-Index - 126
eISSN - 1439-7633
pISSN - 1439-4227
DOI - 10.1002/cbic.200300835
Subject(s) - calorie restriction , sirtuin , resveratrol , polyphenol , sirtuin 1 , saccharomyces cerevisiae , wine , yeast , biochemistry , biology , chemistry , acetylation , food science , downregulation and upregulation , antioxidant , gene , endocrinology
Staying young : The plant phenol stilbene, resveratrol ( 1 ), mimics calorie restriction in the yeast Saccharomyces cerevisiae by increasing life span by 70 % through the activation of the sirtuin Sir2 deacetylase. This simple plant phenol, notably found in red wine, also stimulates the human sirtuin SIRT1 that promotes cell survival by negatively regulating p53.