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Drug Identification through in vivo Screening of Chemical Libraries
Author(s) -
Brown Darren M.,
Pellecchia Maurizio,
Ruoslahti Erkki
Publication year - 2004
Publication title -
chembiochem
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.05
H-Index - 126
eISSN - 1439-7633
pISSN - 1439-4227
DOI - 10.1002/cbic.200300824
Subject(s) - drug discovery , in vivo , drug , chemistry , pharmacokinetics , computational biology , identification (biology) , pharmacology , combinatorial chemistry , biology , biochemistry , genetics , botany
Drug discovery process stood on its head? A proof‐of‐principle study has shown that large numbers of chemical compounds can be tested for selective accumulation in individual tissues in live mice. The picture shows how the site of accumulation of the tail‐vein‐injected molecules could be determined by mass spectrometry. The process picks drug candidates based on tissue specificity and pharmacokinetics rather than defined activity, which is the usual starting point of drug discovery.