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Probing Protein–Carbohydrate Interactions with Microarrays of Synthetic Oligosaccharides
Author(s) -
Ratner Daniel M.,
Adams Eddie W.,
Su Jing,
O'Keefe Barry R.,
Mrksich Milan,
Seeberger Peter H.
Publication year - 2004
Publication title -
chembiochem
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.05
H-Index - 126
eISSN - 1439-7633
pISSN - 1439-4227
DOI - 10.1002/cbic.200300804
Subject(s) - dna microarray , surface plasmon resonance , microarray , carbohydrate , chemistry , mannose , biochemistry , high throughput screening , protein microarray , computational biology , biology , nanotechnology , gene , materials science , gene expression , nanoparticle
On the spot : Carbohydrate microarrays, in concert with surface plasmon resonance, are valuable tools in the rapid identification of carbohydrate–protein interactions, like those between high‐mannose oligosaccharides and cyanovirin‐N (see picture). By utilizing chemical methods amenable to current high‐throughput screening technologies, high‐density carbohydrate microarrays can be prepared and screened by using conventional and widely accessible DNA microarray screening instrumentation.