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Lighting Up Biochemiluminescence by the Surface Self‐Assembly of DNA–Hemin Complexes
Author(s) -
Xiao Yi,
Pavlov Valeri,
Gill Ron,
Bourenko Tatyana,
Willner Itamar
Publication year - 2004
Publication title -
chembiochem
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.05
H-Index - 126
eISSN - 1439-7633
pISSN - 1439-4227
DOI - 10.1002/cbic.200300794
Subject(s) - deoxyribozyme , hemin , g quadruplex , dna , nucleic acid , chemiluminescence , luminol , chemistry , peroxidase , combinatorial chemistry , biochemistry , heme , enzyme , organic chemistry
Illuminating DNA : The assembly of two tailored nucleic acids (colored blue and brown in the scheme) in the presence of hemin yields a G‐quadruplex that exhibits peroxidase‐like activity and catalyzes the generation of chemiluminescence in the presence of H 2 O 2 and luminol. The DNAzyme is employed for the analysis of DNA (green) in solution and on surfaces.