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Rational Saccharide Extension by Using the Natural Product Glycosyltransferase LanGT4
Author(s) -
Hoffmeister Dirk,
Weber Monika,
Dräger Gerald,
Ichinose Koji,
Dürr Clemens,
Bechthold Andreas
Publication year - 2004
Publication title -
chembiochem
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.05
H-Index - 126
eISSN - 1439-7633
pISSN - 1439-4227
DOI - 10.1002/cbic.200300793
Subject(s) - glycosyltransferase , tetrasaccharide , trisaccharide , streptomyces fradiae , chemistry , natural product , glycosylation , stereochemistry , biochemistry , streptomyces , polysaccharide , biology , gene , bacteria , actinomycetales , genetics
Adding more sugar : Overexpression of the landomycin glycosyltransferase gene lanGT4 in Streptomyces fradiae Tü2717 resulted in the conversion of the urdamycin trisaccharide into an unnatural tetrasaccharide by transfer of an L‐rhodinose unit. We propose that LanGT4 is able to act iteratively on growing saccharide chains.