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Expanding the Diversity of Unnatural Cell‐Surface Sialic Acids
Author(s) -
Luchansky Sarah J.,
Goon Scarlett,
Bertozzi Carolyn R.
Publication year - 2004
Publication title -
chembiochem
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.05
H-Index - 126
eISSN - 1439-7633
pISSN - 1439-4227
DOI - 10.1002/cbic.200300789
Subject(s) - bioorthogonal chemistry , sialic acid , glycoconjugate , chemistry , functional diversity , biochemistry , glycan , cell , computational biology , combinatorial chemistry , click chemistry , biology , glycoprotein , ecology
of sialic acid analogues to cells, rather than their upstream N ‐acetylmannosamine (ManNAc) precursors, improves the delivery of bioorthogonal functional groups to the cell surface and enables the incorporation of photoactivatable azides into glycoconjugates (see scheme).
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