A Powerful Antiradiation Compound Revealed by a New High‐Throughput Screening Method | Zendy

Meunier Stéphane | Zendy; DesageEl Murr Marine | Zendy; Nowaczyk Stéphanie | Zendy; Le Gall Thierry | Zendy; Pin Serge | Zendy; Renault JeanPhilippe | Zendy; Boquet Didier | Zendy; Crémi Christophe | Zendy; SaintAman Eric | Zendy; Valleix Alain | Zendy; Taran Frédéric | Zendy; Mioskowski Charles | Zendy

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A Powerful Antiradiation Compound Revealed by a New High‐Throughput Screening Method

Author(s) -

Meunier Stéphane,

DesageEl Murr Marine,

Nowaczyk Stéphanie,

Le Gall Thierry,

Pin Serge,

Renault JeanPhilippe,

Boquet Didier,

Crémi Christophe,

SaintAman Eric,

Valleix Alain,

Taran Frédéric,

Mioskowski Charles

Publication year - 2004

Publication title -

chembiochem

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.05

H-Index - 126

eISSN - 1439-7633

pISSN - 1439-4227

DOI - 10.1002/cbic.200300787

Subject(s) - high throughput screening , chemistry , throughput , combinatorial chemistry , chromatography , biochemistry , computer science , telecommunications , wireless

We present a new high‐throughput screening method for the selection of powerful water‐soluble antiradiation compounds. This method, which uses conventional immunoassay techniques, allowed the capacity of a given compound to protect thymidine from irradiation to be evaluated. By applying this assay to an antioxidant library, we showed for the first time that norbadione A, a well‐known mushroom pigment, has pronounced atypical antiradiation properties.

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