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A Powerful Antiradiation Compound Revealed by a New High‐Throughput Screening Method
Author(s) -
Meunier Stéphane,
DesageEl Murr Marine,
Nowaczyk Stéphanie,
Le Gall Thierry,
Pin Serge,
Renault JeanPhilippe,
Boquet Didier,
Crémi Christophe,
SaintAman Eric,
Valleix Alain,
Taran Frédéric,
Mioskowski Charles
Publication year - 2004
Publication title -
chembiochem
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.05
H-Index - 126
eISSN - 1439-7633
pISSN - 1439-4227
DOI - 10.1002/cbic.200300787
Subject(s) - high throughput screening , chemistry , throughput , combinatorial chemistry , chromatography , biochemistry , computer science , telecommunications , wireless
We present a new high‐throughput screening method for the selection of powerful water‐soluble antiradiation compounds. This method, which uses conventional immunoassay techniques, allowed the capacity of a given compound to protect thymidine from irradiation to be evaluated. By applying this assay to an antioxidant library, we showed for the first time that norbadione A, a well‐known mushroom pigment, has pronounced atypical antiradiation properties.