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Template‐Directed Assembly of Metallosalen–DNA Hairpin Conjugates
Author(s) -
Czlapinski Jennifer L.,
Sheppard Terry L.
Publication year - 2004
Publication title -
chembiochem
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.05
H-Index - 126
eISSN - 1439-7633
pISSN - 1439-4227
DOI - 10.1002/cbic.200300776
Subject(s) - oligonucleotide , dna , conjugate , combinatorial chemistry , chemistry , salicylaldehyde , template , computational biology , biochemistry , stereochemistry , nanotechnology , biology , materials science , mathematical analysis , schiff base , mathematics
Encoded assembly : Hairpin metallosalen–DNA was assembled from two salicylaldehyde‐modified, complementary oligonucleotides by DNA template‐directed synthesis. Assembly reactions in the absence of divalent metal ions produced a new class of metal‐free salen–DNA hairpin constructs. Metallosalen–DNA hairpin conjugates demonstrated high B‐form duplex stability, which may facilitate structural studies of metallosalen–DNA conjugates.