In Vitro Inhibition of Human Immunodeficiency Virus Type‐1 (HIV‐1) Reverse Transcriptase by Gold( III ) Porphyrins | Zendy

Sun Raymond WaiYin | Zendy; Yu WingYiu | Zendy; Sun Hongzhe | Zendy; Che ChiMing | Zendy

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In Vitro Inhibition of Human Immunodeficiency Virus Type‐1 (HIV‐1) Reverse Transcriptase by Gold( III ) Porphyrins

Author(s) -

Sun Raymond WaiYin,

Yu WingYiu,

Sun Hongzhe,

Che ChiMing

Publication year - 2004

Publication title -

chembiochem

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.05

H-Index - 126

eISSN - 1439-7633

pISSN - 1439-4227

DOI - 10.1002/cbic.200300773

Subject(s) - reverse transcriptase , in vitro , chemistry , human immunodeficiency virus (hiv) , cytotoxicity , cationic polymerization , ic50 , porphyrin , colloidal gold , virology , microbiology and biotechnology , biochemistry , biology , rna , nanoparticle , nanotechnology , organic chemistry , materials science , gene

A cationic gold( III ) porphyrin , [Au III (TMPyP)]Cl 5 ( 1 a ), is a potent HIV‐1 reverse transcriptase inhibitor in vitro with an IC 50 value=0.31 μ M . Effective inhibition (67 %) can be produced by the “ 1 a + AZT‐TP” protocol at nanomolar level. The gold( III ) complex exhibits remarkable stability in physiological buffer without significant cytotoxicity to normal T cells.

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