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In Vitro Inhibition of Human Immunodeficiency Virus Type‐1 (HIV‐1) Reverse Transcriptase by Gold( III ) Porphyrins
Author(s) -
Sun Raymond WaiYin,
Yu WingYiu,
Sun Hongzhe,
Che ChiMing
Publication year - 2004
Publication title -
chembiochem
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.05
H-Index - 126
eISSN - 1439-7633
pISSN - 1439-4227
DOI - 10.1002/cbic.200300773
Subject(s) - reverse transcriptase , in vitro , chemistry , human immunodeficiency virus (hiv) , cytotoxicity , cationic polymerization , ic50 , porphyrin , colloidal gold , virology , microbiology and biotechnology , biochemistry , biology , rna , nanoparticle , nanotechnology , organic chemistry , materials science , gene
A cationic gold( III ) porphyrin , [Au III (TMPyP)]Cl 5 ( 1 a ), is a potent HIV‐1 reverse transcriptase inhibitor in vitro with an IC 50 value=0.31 μ M . Effective inhibition (67 %) can be produced by the “ 1 a + AZT‐TP” protocol at nanomolar level. The gold( III ) complex exhibits remarkable stability in physiological buffer without significant cytotoxicity to normal T cells.