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Residue‐ and Sequence‐Selective Binding of Nonaromatic Dipeptides by Bis(β‐cyclodextrin) with a Functional Tether
Author(s) -
Liu Yu,
Yang YingWei,
Song Yun,
Zhang HengYi,
Ding Fei,
Wada Takehiko,
Inoue Yoshihisa
Publication year - 2004
Publication title -
chembiochem
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.05
H-Index - 126
eISSN - 1439-7633
pISSN - 1439-4227
DOI - 10.1002/cbic.200300770
Subject(s) - cyclodextrin , chemistry , residue (chemistry) , selectivity , peptide , sequence (biology) , stereochemistry , organic chemistry , biochemistry , catalysis
Do you recognise this peptide? Novel 6,6′‐(2,2′‐dithiobis(2‐(benzoylamino)ethylamino))‐bridged bis(β‐CD), such as the one shown here, showed good to excellent residue selectivities of up to 28 for several nonaromatic dipeptides with the complex stability sequence of Glu‐Glu < Gly‐Gly < Leu‐Gly < Met‐Met < Gly‐Pro < Gly‐Leu, and also a high sequence selectivity of 5.0 for Gly‐Leu versus Leu‐Gly.