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Electrospray Ionization of a Whole Virus: Analyzing Mass, Structure, and Viability
Author(s) -
Bothner Brian,
Siuzdak Gary
Publication year - 2004
Publication title -
chembiochem
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.05
H-Index - 126
eISSN - 1439-7633
pISSN - 1439-4227
DOI - 10.1002/cbic.200300754
Subject(s) - electrospray ionization , electrospray , mass spectrometry , virus , ionization , chemistry , tobacco mosaic virus , ion , chromatography , virology , biology , organic chemistry
Staying together : Electrospray ionization has been shown to generate intact gas‐phase viral ions that can be used to examine mass and structure of whole viruses such as the tabac mosaic virus. That these particles are viable can be demonstrated by the infection of tobacco plants, which then develop characteristic lesions (see picture).