Premium
Sticky Proteins for Stem Cells
Author(s) -
Kolter Thomas
Publication year - 2003
Publication title -
chembiochem
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.05
H-Index - 126
eISSN - 1439-7633
pISSN - 1439-4227
DOI - 10.1002/cbic.200300733
Subject(s) - haematopoiesis , stem cell , wnt signaling pathway , microbiology and biotechnology , posttranslational modification , biology , chemistry , computational biology , biochemistry , signal transduction , enzyme
Growing the next generation : Functionally active Wnt proteins are palmitoylated (see scheme). This posttranslational modification explains the ability of Wnt proteins to associate tightly with membranes and is required for the induction of self‐renewal and proliferation of haematopoietic stem cells.