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Gold Glyconanoparticles as New Tools in Antiadhesive Therapy
Author(s) -
Rojo Javier,
Díaz Vicente,
de la Fuente Jesús M.,
Segura Inmaculada,
Barrientos Africa G.,
Riese Hans H.,
Bernad Antonio,
Penadés Soledad
Publication year - 2004
Publication title -
chembiochem
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.05
H-Index - 126
eISSN - 1439-7633
pISSN - 1439-4227
DOI - 10.1002/cbic.200300726
Subject(s) - nanotechnology , engineering , materials science
Abstract Gold glyconanoparticles (GNPs) have been prepared as new multivalent tools that mimic glycosphingolipids on the cell surface. GNPs are highly soluble under physiological conditions, stable against enzymatic degradation and nontoxic. Thereby GNPs open up a novel promising multivalent platform for biological applications. It has recently been demonstrated that specific tumor‐associated carbohydrate antigens (glycosphingolipids and glycoproteins) are involved in the initial step of tumor spreading. A mouse melanoma model was selected to test glyconanoparticles as possible inhibitors of experimental lung metastasis. A carbohydrate–carbohydrate interaction is proposed as the first recognition step for this process. Glyconanoparticles presenting lactose ( lacto ‐GNPs) have been used successfully to significantly reduce the progression of experimental metastasis. This result shows for the first time a clear biological effect of lacto ‐GNPs, demonstrating the potential application of this glyconanotechnology in biological processes.