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Synthetic Peptides Derived from the Angiostatin K4 Domain Inhibit Endothelial Cell Migration
Author(s) -
Dettin Monica,
Bicciato Silvio,
Scarinci Claudia,
Cline Edith,
Lingen Mark W.,
Di Bello Carlo
Publication year - 2003
Publication title -
chembiochem
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.05
H-Index - 126
eISSN - 1439-7633
pISSN - 1439-4227
DOI - 10.1002/cbic.200300711
Subject(s) - angiostatin , motility , peptide , domain (mathematical analysis) , chemistry , cell migration , sequence (biology) , inhibitory postsynaptic potential , cell , microbiology and biotechnology , loop (graph theory) , biophysics , computational biology , biochemistry , biology , angiogenesis , cancer research , mathematics , mathematical analysis , neuroscience , combinatorics
Loop the loop: Several linear and cyclic peptides patterned on the angiostatin K4 domain (see picture) have been synthesized and tested in order to identify active sequence candidates for further studies aimed at elucidating the antimigratory activity and functionality of the K4 domain. Migration assays indicate that different K4 regions induce different degrees of inhibition of cell motility. In particular, the linear peptide reproducing the (358–379) fragment of angiostatin exhibits an inhibitory activity comparable to that of the entire K4 domain.