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Targeting the HIV Trans ‐Activation Responsive Region—Approaches Towards RNA‐Binding Drugs
Author(s) -
Krebs Andreas,
Ludwig Verena,
Boden Oliver,
Göbel Michael W.
Publication year - 2003
Publication title -
chembiochem
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.05
H-Index - 126
eISSN - 1439-7633
pISSN - 1439-4227
DOI - 10.1002/cbic.200300652
Subject(s) - rna , tar (computing) , human immunodeficiency virus (hiv) , computational biology , chemistry , riboswitch , rna binding protein , biology , microbiology and biotechnology , biochemistry , virology , non coding rna , gene , computer science , programming language
Sticking to TAR : The development of RNA‐binding drugs will open fascinating opportunities for modern pharmacology. Experience in how to find ligands for RNA targets, however, is still limited. Lessons learnt from well‐characterized RNA–protein complexes such as tat/TAR, therefore, will significantly contribute to the future development of the field. TAR RNA, the trans ‐activation responsive region of HIV, and the tat protein form a molecular switch crucial for viral replication. Herein we review the state of research concerning TAR‐binding molecules and the techniques used to study RNA–ligand association.