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Macrophomate Synthase: The First Structure of a Natural Diels–Alderase
Author(s) -
Pohnert Georg
Publication year - 2003
Publication title -
chembiochem
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.05
H-Index - 126
eISSN - 1439-7633
pISSN - 1439-4227
DOI - 10.1002/cbic.200300651
Subject(s) - atp synthase , enzyme , chemistry , active site , carbon fibers , catalysis , stereochemistry , crystal structure , organic chemistry , materials science , composite number , composite material
An enzyme‐catalyzed Diels–Alder reaction in the formation of macrophomic acid can be deduced from the crystal structure of macrophomate synthase. The active site of the Diels–Alderase allows to explain how the single enzyme promotes two carbon–carbon bond formations, two decarboxylations and a dehydration step (see scheme).