Evidence for the Combined Participation of a C 10  and a C 15  Precursor in the Biosynthesis of Moenocinol, the Lipid Part of the Moenomycin Antibiotics | Zendy

Neundorf Ines | Zendy; Köhler Christian | Zendy; Hennig Lothar | Zendy; Findeisen Matthias | Zendy; Arigoni Duilio | Zendy; Welzel Peter | Zendy

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Evidence for the Combined Participation of a C 10 and a C 15 Precursor in the Biosynthesis of Moenocinol, the Lipid Part of the Moenomycin Antibiotics

Author(s) -

Neundorf Ines,

Köhler Christian,

Hennig Lothar,

Findeisen Matthias,

Arigoni Duilio,

Welzel Peter

Publication year - 2003

Publication title -

chembiochem

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.05

H-Index - 126

eISSN - 1439-7633

pISSN - 1439-4227

DOI - 10.1002/cbic.200300622

Subject(s) - biosynthesis , chemistry , stereochemistry , antibiotics , streptomyces , starter , deuterium , biochemistry , bacteria , biology , food science , gene , physics , quantum mechanics , genetics

Upon feeding of [2‐ 13 C,4‐ 2 H]‐1‐deoxy‐ D ‐xylulose to Streptomyces ghanaensis, the deuterium label was retained exclusively at positions C‐7 and C‐17 in the moenocinol part of the moenomycin antibiotics. This result vindicates the hypothesis that the C 25 structure of moenocinol is assembled from a C 10 and a C 15 precursor, each of which requires for its formation the involvement of a dimethylallyl diphosphate starter unit.

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