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Evidence for the Combined Participation of a C 10 and a C 15 Precursor in the Biosynthesis of Moenocinol, the Lipid Part of the Moenomycin Antibiotics
Author(s) -
Neundorf Ines,
Köhler Christian,
Hennig Lothar,
Findeisen Matthias,
Arigoni Duilio,
Welzel Peter
Publication year - 2003
Publication title -
chembiochem
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.05
H-Index - 126
eISSN - 1439-7633
pISSN - 1439-4227
DOI - 10.1002/cbic.200300622
Subject(s) - biosynthesis , chemistry , stereochemistry , antibiotics , streptomyces , starter , deuterium , biochemistry , bacteria , biology , food science , gene , physics , quantum mechanics , genetics
Abstract Upon feeding of [2‐ 13 C,4‐ 2 H]‐1‐deoxy‐ D ‐xylulose to Streptomyces ghanaensis, the deuterium label was retained exclusively at positions C‐7 and C‐17 in the moenocinol part of the moenomycin antibiotics. This result vindicates the hypothesis that the C 25 structure of moenocinol is assembled from a C 10 and a C 15 precursor, each of which requires for its formation the involvement of a dimethylallyl diphosphate starter unit.