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Bromobalhimycin and Chlorobromobalhimycins—Illuminating the Potential of Halogenases in Glycopeptide Antibiotic Biosyntheses
Author(s) -
Bister Bojan,
Bischoff Daniel,
Nicholson Graeme J.,
Stockert Sigrid,
Wink Joachim,
Brunati Cristina,
Donadio Stefano,
Pelzer Stefan,
Wohlleben Wolfgang,
Süssmuth Roderich D.
Publication year - 2003
Publication title -
chembiochem
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.05
H-Index - 126
eISSN - 1439-7633
pISSN - 1439-4227
DOI - 10.1002/cbic.200300619
Subject(s) - substituent , glycopeptide , moiety , chemistry , bromide , fermentation , bromine , vancomycin , antibiotics , bacteria , stereochemistry , combinatorial chemistry , biochemistry , organic chemistry , biology , genetics , staphylococcus aureus
Can bromine beat bacteria? By varying the amounts of chloride and bromide salts in fermentation culture media, we have generated novel sets of vancomycin‐type glycopeptides with bromine substitution. This study extends the sequence of substituents at the aglycon moiety of balhimycin from H through F and Cl to Br (see scheme) and opens up possibilites for the investigation of substituent effects upon the activity of glycopeptide antibiotics.