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Novel Factor XIII Probes for Blood Coagulation Imaging
Author(s) -
Tung ChingHsuan,
Ho NanHui,
Zeng Qing,
Tang Yi,
Jaffer Farouc A.,
Reed Guy L.,
Weissleder Ralph
Publication year - 2003
Publication title -
chembiochem
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.05
H-Index - 126
eISSN - 1439-7633
pISSN - 1439-4227
DOI - 10.1002/cbic.200300602
Subject(s) - factor xiii , coagulation , tissue transglutaminase , fluorescence , medicine , absorbance , clot formation , chemistry , pathology , biochemistry , fibrinogen , chromatography , optics , physics , enzyme
The clot thickens : An α2‐antiplasmin peptide fragment labeled with a near‐infrared fluorochrome or a paramagnetic reporter (see figure) can be used for imaging blood clot formation. A thrombosis‐specific probe was developed based on blood coagulation factor XIII transglutaminase but the approach could be extended to other transglutaminases involved in diseases such as cancer, neurodegenerative diseases and celiac disease. The use of near‐infrared fluorescence avoids the difficulty of background absorbance encountered when light imaging is used for blood imaging.