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New Light on a Long‐Known Protein Family
Author(s) -
Andersen Olav M.,
Petersen Helle H.
Publication year - 2003
Publication title -
chembiochem
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.05
H-Index - 126
eISSN - 1439-7633
pISSN - 1439-4227
DOI - 10.1002/cbic.200300580
Subject(s) - endocytosis , receptor , protein family , biology , ldl receptor , signal transduction , g protein coupled receptor , microbiology and biotechnology , computational biology , biochemistry , cholesterol , lipoprotein , gene
A family affair : The view of the LDLR family has shifted from a family of endocytosis receptors towards a class of membrane proteins participating in complex signaling pathways. The receptors play essential roles in several physiological processes but are also involved in many pathological events, such as atherosclerosis and Alzheimer's disease; this makes them attractive drug targets.