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CD157, the Janus of CD38 but with a unique personality
Author(s) -
Ortolan Erika,
Vacca Paola,
Capobianco Andrea,
Armando Enrico,
Crivellin Federico,
Horenstein Alberto,
Malavasi Fabio
Publication year - 2002
Publication title -
cell biochemistry and function
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.933
H-Index - 61
eISSN - 1099-0844
pISSN - 0263-6484
DOI - 10.1002/cbf.978
Subject(s) - cd38 , nad+ kinase , janus , extracellular , receptor , microbiology and biotechnology , biology , gene , biochemistry , computational biology , enzyme , nanotechnology , stem cell , materials science , cd34
CD157 is a pleiotropic ectoenzyme which belongs to the CD38 family and to the growing number of leukocyte surface molecules known to act independently as both receptors and enzymes. A 45‐kDa surface structure with a GPI anchor, the CD157 molecule displays two distinct domains in its extracellular component. The first is implicated in the enzymic activities of the molecule and the second features adhesion/signalling properties. CD157 shares several characteristics with CD38, including a similar amino acid sequence and enzymic functions. Both molecules are involved in the metabolism of NAD + , and the CD157 gene is synthenic on 4p15 with CD38 , with which it also shares a unique genomic organization. Their conservation in phylogeny is striking evidence for their relevance in the life and death cycle of the cell. Copyright © 2002 John Wiley & Sons, Ltd.