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Transcriptional activation of the human insulin receptor gene by 1,25‐dihydroxyvitamin D 3
Author(s) -
Maestro B.,
Molero S.,
Bajo S.,
Dávila N.,
Calle C.
Publication year - 2002
Publication title -
cell biochemistry and function
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.933
H-Index - 61
eISSN - 1099-0844
pISSN - 0263-6484
DOI - 10.1002/cbf.951
Subject(s) - insulin , insulin receptor , receptor , human insulin , gene , calcitriol receptor , microbiology and biotechnology , chemistry , biology , endocrinology , biochemistry , insulin resistance
Treatment with 10 −8 m 1,25‐dihydroxyvitamin D 3 for 24 h causes transcriptional activation of the human insulin receptor gene in U‐937 human promonocytic cells. The activation seems to potentiate the response to insulin in terms of glucose oxidation. Wortmannin, a phosphatidylinositol 3‐kinase inhibitor, causes a greater inhibition of insulin‐stimulated glucose oxidation in 1,25‐dihydroxyvitamin D 3 ‐treated cells than in untreated cells. This suggests a stimulation of phosphatidylinositol 3‐kinase activity by 1,25‐dihydroxyvitamin D 3 , which could mediate, at least in part, the potentiation of the insulin response. Copyright © 2002 John Wiley & Sons, Ltd.