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Lipid peroxidation and antioxidant enzyme levels in patients with schizophrenia and bipolar disorder
Author(s) -
Kuloglu Murat,
Ustundag Bilal,
Atmaca Murad,
Canatan Halit,
Tezcan A. Ertan,
Cinkilinc Nadire
Publication year - 2002
Publication title -
cell biochemistry and function
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.933
H-Index - 61
eISSN - 1099-0844
pISSN - 0263-6484
DOI - 10.1002/cbf.940
Subject(s) - lipid peroxidation , glutathione peroxidase , bipolar disorder , superoxide dismutase , malondialdehyde , schizophrenia (object oriented programming) , medicine , antioxidant , glutathione , endocrinology , psychology , chemistry , enzyme , oxidative stress , biochemistry , psychiatry , lithium (medication)
Abstract Recent data from several reports indicate that free radicals are involved in aetiopathogenesis of many human pathologies including neuropsychiatric disorders such as schizophrenia, bipolar disorder etc. In the present study, we aimed at determining and evaluating levels of malondialdehyde (MDA), a product of lipid peroxidation, and antioxidant enzyme superoxide dismutase (SOD) and glutathione peroxidase (GSH‐Px) activity levels in patients diagnosed with schizophrenia ( n = 25) and bipolar disorder ( n = 23). The control group was composed of 20 healthy subjects. There was a significant increase in MDA levels of patients with schizophrenia and bipolar disorder compared with controls. SOD and GSH‐Px activity levels were significantly higher in the schizophrenic group compared with controls. SOD activity levels in bipolar the group were significantly higher than controls whereas there were no significant changes in GSH‐Px activity levels in the bipolar group and controls. Significant differences between lipid peroxidation product and antioxidant enzyme (SOD and GSH‐Px) activity levels in schizophrenic and bipolar disorder patients compared with controls leads us to believe that these differences are related to the heterogenities in aetiologies of these disorders. Copyright © 2002 John Wiley & Sons, Ltd.