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The natural substrate for nitric oxide synthase activity
Author(s) -
AlaghbandZadeh Jamshid,
Mehdizadeh Siroos,
Khan Nusrat S,
Farrell Anne O',
Bitensky Lucille,
Chayen Joseph
Publication year - 2001
Publication title -
cell biochemistry and function
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.933
H-Index - 61
eISSN - 1099-0844
pISSN - 0263-6484
DOI - 10.1002/cbf.930
Subject(s) - nitric oxide synthase , substrate (aquarium) , arginine , nitric oxide , chemistry , biochemistry , citrulline , atp synthase , enzyme , biology , amino acid , organic chemistry , ecology
Abstract There has been little evidence to indicate that arginine is the natural substrate for generating nitric oxide synthase (NOS) activity. It is now shown that carnosine, which is widely distributed in tissues, is likely to be the true substrate. In tissue sections it gives a stronger NOS reaction than does arginine. Copyright © 2001 John Wiley & Sons, Ltd.

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