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Chemopreventive efficacy of selenium against N‐nitrosodiethylamine‐induced hepatoma in albino rats
Author(s) -
Thirunavukkarasu C.,
Prince Vijeya Singh J.,
Selvendiran K.,
Sakthisekaran D.
Publication year - 2001
Publication title -
cell biochemistry and function
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.933
H-Index - 61
eISSN - 1099-0844
pISSN - 0263-6484
DOI - 10.1002/cbf.924
Subject(s) - isocitrate dehydrogenase , malate dehydrogenase , selenium , citric acid cycle , succinate dehydrogenase , dehydrogenase , carcinogen , biochemistry , enzyme , chemistry , biology , organic chemistry
The chemopreventive/chemotherapeutic effect of sodium selenite on tricarboxylic acid cycle key enzymes was investigated against hepatoma induced by environmental carcinogen N‐nitrosodiethylamine. Decreased activities of TCA cycle key enzymes such as isocitrate dehydrogenase (ICDH), succinate dehydrogenase (SDH), malate dehydrogenase (MDH) and α‐ketoglutarate dehydrogenase (α‐KGDH) in hepatoma and surrounding tissues of hepatoma‐bearing rats were observed. Upon selenium supplementation the above biochemical changes were reverted in a dose‐ and duration‐dependent manner. This study further confirms the chemopreventive/chemotherapeutic effect of sodium selenite which is found to be more effective in the initiation phase of carcinogenesis. Copyright © 2001 John Wiley & Sons, Ltd.