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Effects of Se, Cu and Se + vitamin E deficiency on the activities of CuZnSOD, GSH‐Px, CAT and LPO levels in chicken erythrocytes
Author(s) -
Bozkaya Lütfiye Arzu,
ÖztürkÜrek Raziye,
Aydemir Tülin,
Tarhan Leman
Publication year - 2001
Publication title -
cell biochemistry and function
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.933
H-Index - 61
eISSN - 1099-0844
pISSN - 0263-6484
DOI - 10.1002/cbf.906
Subject(s) - chemistry , vitamin e , medicine , antioxidant , lipid peroxide , endocrinology , enzyme , vitamin e deficiency , vitamin , reactive oxygen species , biochemistry , lipid peroxidation , biology
Abstract Antioxidant enzymes and vitamins provide a defence against the damage of cells by reactive oxygen species in living systems. The effect of Cu, Se and vitamin E deficiencies on the antioxidant enzyme activities and lipid peroxide levels of chicken erythrocytes were investigated during 6 weeks of a depletion diet. CuZnSOD activity and the plasma Cu level of the Cu‐deficient group which was fed a diet containing 0.2 mg Cu kg −1 were reduced to 62 and 71% respectively. GSH‐Px activity of the Se‐deficient group was decreased by 46% but by 21% in the Cu‐deficient group. CAT activity values of Se‐ and Cu‐deficient groups were increased by 28 and 10% respectively. The maximum increase of LPO levels in erythrocyte membranes was observed as 32% for the Se+E‐deficient group. The LPO level of the Cu‐deficient group which had decreased CuZnSOD and GSH‐Px activity, was also observed to be significantly increased when compared with the controls ( p < 0.05). Copyright © 2001 John Wiley & Sons, Ltd.