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Hepatic fatty acid‐supported respiration in rats fed an energy‐dense diet
Author(s) -
Liverini Giovanna,
Iossa Susanna,
Mollica Maria P.,
Lionetti Lillà,
Barletta Antonio
Publication year - 1996
Publication title -
cell biochemistry and function
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.933
H-Index - 61
eISSN - 1099-0844
pISSN - 0263-6484
DOI - 10.1002/cbf.692
Subject(s) - respiration , fatty acid , chemistry , energy metabolism , biochemistry , fatty liver , food science , zoology , medicine , endocrinology , biology , botany , disease
The energy balance and hepatic fatty acid‐supported respiration were studied in rats fed a control or an energy‐dense diet. In addition, state 3 and 4 respiratory rates as well as ketone body production with palmitoylcarnitine as substrate were determined in isolated mitochondria. Metabolizable energy intake and energy expenditure increased in rats fed an energy‐dense diet, but the gain in body weight and lipid content remained unchanged. No variation occurred in the mitochondrial palmitoylcarnitine utilization rate and ketone body production, but a significant increase in the mitochondrial content of ketone bodies and the serum levels was found in rats fed an energy‐dense diet. Furthermore, we have shown a significant increase in fatty acid‐stimulated respiration in hepatocytes from rats fed an energy‐dense diet. The enhanced hepatic fatty acid utilization as an energy substrate found in rats fed an energy‐dense diet may contribute to reduce the availability of lipids for storage, thus counteracting the development of obesity.