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Interaction between Na ions and the Cl/HCO 3 exchanger in basolateral membranes from rat jejunum
Author(s) -
Orsenigo M. N.,
Tosco M.,
Faelli A.
Publication year - 1996
Publication title -
cell biochemistry and function
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.933
H-Index - 61
eISSN - 1099-0844
pISSN - 0263-6484
DOI - 10.1002/cbf.648
Subject(s) - epithelial polarity , sodium–hydrogen antiporter , membrane , sodium , biophysics , chemistry , intracellular , extracellular , vesicle , ion exchange , intracellular ph , ion , biochemistry , biology , organic chemistry
The jejunal basolateral Cl/HCO 3 exchanger is modulated by two Na‐dependent regulatory sites located on the inner and outer membrane surfaces. The aim of this work was to focus on the interaction between the anion exchanger and intracellular or extracellular sodium. Uptake studies, performed using basolateral membrane vesicles, provided kinetic parameters as a function of outside or inside Na concentration. The intracellular Na‐sensitive modifier site seems to be primarily involved in the modulation of the Cl/HCO 3 exchanger.