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The effect of insulin on macrophage metabolism and function
Author(s) -
Rosa Luís F. B. P. Costa,
Safi Danilo A.,
Cury Yara,
Curi Rui
Publication year - 1996
Publication title -
cell biochemistry and function
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.933
H-Index - 61
eISSN - 1099-0844
pISSN - 0263-6484
DOI - 10.1002/cbf.637
Subject(s) - insulin , macrophage , function (biology) , metabolism , chemistry , biology , microbiology and biotechnology , biochemistry , endocrinology , in vitro
This study examined the effect of insulin on rat macrophage metabolism and function. The following parameters were studied: cell migration in response to thioglycollate and BCG stimuli, macrophage phagocytic capacity, H 2 O 2 production, glucose and glutamine metabolism as indicated by the measurement of enzyme activities, the utilization of metabolites and production and oxidation of substrates. The results indicate that insulin: (1) did not affect cell migration in response to thioglycollate and BCG; (2) enhanced the phagocytic capacity of macrophages and the production of H 2 O 2 by macrophages; (3) increased the metabolism of glucose and reduced that of glutaminase.