The effect of insulin on macrophage metabolism and function | Zendy

Rosa Luís F. B. P. Costa | Zendy; Safi Danilo A. | Zendy; Cury Yara | Zendy; Curi Rui | Zendy

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The effect of insulin on macrophage metabolism and function

Author(s) -

Rosa Luís F. B. P. Costa,

Safi Danilo A.,

Cury Yara,

Curi Rui

Publication year - 1996

Publication title -

cell biochemistry and function

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.933

H-Index - 61

eISSN - 1099-0844

pISSN - 0263-6484

DOI - 10.1002/cbf.637

Subject(s) - insulin , macrophage , function (biology) , metabolism , chemistry , biology , microbiology and biotechnology , biochemistry , endocrinology , in vitro

This study examined the effect of insulin on rat macrophage metabolism and function. The following parameters were studied: cell migration in response to thioglycollate and BCG stimuli, macrophage phagocytic capacity, H 2 O 2 production, glucose and glutamine metabolism as indicated by the measurement of enzyme activities, the utilization of metabolites and production and oxidation of substrates. The results indicate that insulin: (1) did not affect cell migration in response to thioglycollate and BCG; (2) enhanced the phagocytic capacity of macrophages and the production of H 2 O 2 by macrophages; (3) increased the metabolism of glucose and reduced that of glutaminase.

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