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Targeting ubiquitin specific protease 7 in cancer: A deubiquitinase with great prospects
Author(s) -
Yeasmin Khusbu Farjana,
Chen FangZhi,
Chen HanChun
Publication year - 2018
Publication title -
cell biochemistry and function
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.933
H-Index - 61
eISSN - 1099-0844
pISSN - 0263-6484
DOI - 10.1002/cbf.3336
Subject(s) - deubiquitinating enzyme , ubiquitin , chromatin , epigenetics , chromatin remodeling , carcinogenesis , biology , microbiology and biotechnology , proteases , ubiquitin ligase , protease , computational biology , cancer , dna , enzyme , genetics , biochemistry , gene
Deubiquitinase (DUB)‐mediated cleavage of ubiquitin chain balances ubiquitination and deubiquitination for determining protein fate. USP7 is one of the best characterized DUBs and functionally important. Numerous proteins have been identified as potential substrates and binding partners of USP7; those play crucial roles in diverse array of cellular and biological processes including tumour suppression, cell cycle, DNA repair, chromatin remodelling, and epigenetic regulation. This review aims at summarizing the current knowledge of this wide association of USP7 with many cellular processes that enlightens the possibility of abnormal USP7 activity in promoting oncogenesis and the importance of identification of specific inhibitors.