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Mechanistic insight into nuclear receptor‐mediated regulation of bile acid metabolism and lipid homeostasis by grape seed procyanidin extract (GSPE)
Author(s) -
Downing Laura E.,
Edgar Daniel,
Ellison Patricia A.,
Ricketts MarieLouise
Publication year - 2017
Publication title -
cell biochemistry and function
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.933
H-Index - 61
eISSN - 1099-0844
pISSN - 0263-6484
DOI - 10.1002/cbf.3247
Subject(s) - grape seed extract , nuclear receptor , bile acid , lipid metabolism , biochemistry , grape seed , proanthocyanidin , metabolic pathway , biology , homeostasis , receptor , in vivo , metabolism , chemistry , pharmacology , microbiology and biotechnology , antioxidant , medicine , food science , polyphenol , transcription factor , gene , alternative medicine , pathology
Dietary procyanidins have emerged as important bioactive components that regulate various metabolic pathways to maintain homeostasis. Grape seed procyanidin extract (GSPE), in particular, has demonstrated regulatory effects on bile acid and lipid metabolism in vivo. While numerous studies in rodent models have shown the potent hypolipidemic action of grape seed extracts, human studies have shown inconsistent results. This review will focus on the molecular mechanisms underlying the hypolipidemic actions of GSPE identified to date, specifically highlighting the effects exerted via nuclear receptors. Such evidence may provide avenues for future research in human subjects with GSPE as a therapeutic treatment for the prevention and amelioration of the metabolic syndrome and cardiovascular disease.