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α ‐Lipoic acid inhibits sevoflurane‐induced neuronal apoptosis through PI3K/Akt signalling pathway
Author(s) -
Ma Rong,
Wang Xiang,
Peng Peipei,
Xiong Jingwei,
Dong Hongquan,
Wang Lixia,
Ding Zhengnian
Publication year - 2016
Publication title -
cell biochemistry and function
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.933
H-Index - 61
eISSN - 1099-0844
pISSN - 0263-6484
DOI - 10.1002/cbf.3163
Subject(s) - sevoflurane , morris water navigation task , apoptosis , pi3k/akt/mtor pathway , medicine , hippocampal formation , lipoic acid , hippocampus , pharmacology , hedgehog signaling pathway , postoperative cognitive dysfunction , anesthesia , neuroscience , cognition , signal transduction , chemistry , psychology , endocrinology , psychiatry , antioxidant , biochemistry
Sevoflurane is a widely used anaesthetic agent, including in anaesthesia of children and infants. Recent studies indicated that the general anaesthesia might cause the cell apoptosis in the brain. This issue raises the concerns about the neuronal toxicity induced by the application of anaesthetic agents, especially in the infants and young children. In this study, we used Morris water maze, western blotting and immunohistochemistry to elucidate the role of α ‐lipoic acid in the inhibition of neuronal apoptosis. We found that sevoflurane led to the long‐term cognitive impairment in the young rats. This adverse effect may be caused by the neuronal death in the hippocampal region, mediated through PI3K/Akt signalling pathway. We also showed that α ‐lipoic acid offset the effect of sevoflurane on the neuronal apoptosis and cognitive dysfunction. This study elucidated the potential clinical role of α ‐lipoic acid, providing a promising way in the prevention and treatment of long‐term cognitive impairment induced by sevoflurane general anesthesia. Copyright © 2016 John Wiley & Sons, Ltd.