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Rosmarinic acid prevents lipid peroxidation and increase in acetylcholinesterase activity in brain of streptozotocin‐induced diabetic rats
Author(s) -
Mushtaq Nadia,
Schmatz Roberta,
Pereira Luciane B.,
Ahmad Mushtaq,
Stefanello Naiara,
Vieira Juliano M.,
Abdalla Fátima,
Rodrigues Marília V.,
Baldissarelli Jucimara,
Pelinson Luana Paula,
Dalenogare Diéssica P.,
Reichert Karine Paula,
Dutra Eduardo M.,
Mulinacci Nádia,
Innocenti Marzia,
Bellumori Maria,
Morsch Vera Maria,
Schetinger Maria Rosa
Publication year - 2014
Publication title -
cell biochemistry and function
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.933
H-Index - 61
eISSN - 1099-0844
pISSN - 0263-6484
DOI - 10.1002/cbf.3014
Subject(s) - lipid peroxidation , acetylcholinesterase , streptozotocin , rosmarinic acid , striatum , hippocampus , endocrinology , medicine , oxidative stress , aché , tbars , chemistry , diabetes mellitus , pharmacology , antioxidant , biochemistry , dopamine , enzyme
We investigated the efficacy of rosmarinic acid (RA) in preventing lipid peroxidation and increased activity of acetylcholinesterase (AChE) in the brain of streptozotocin‐induced diabetic rats. The animals were divided into six groups ( n = 8): control, ethanol, RA 10 mg/kg, diabetic, diabetic/ethanol and diabetic/RA 10 mg/kg. After 21 days of treatment with RA, the cerebral structures (striatum, cortex and hippocampus) were removed for experimental assays. The results demonstrated that the treatment with RA (10 mg/kg) significantly reduced the level of lipid peroxidation in hippocampus (28%), cortex (38%) and striatum (47%) of diabetic rats when compared with the control. In addition, it was found that hyperglycaemia caused significant increased in the activity of AChE in hippocampus (58%), cortex (46%) and striatum (30%) in comparison with the control. On the other hand, the treatment with RA reversed this effect to the level of control after 3 weeks. In conclusion, the present findings showed that treatment with RA prevents the lipid peroxidation and consequently the increase in AChE activity in diabetic rats, demonstrating that this compound can modulate cholinergic neurotransmission and prevent damage oxidative in brain in the diabetic state. Thus, we can suggest that RA could be a promising compound in the complementary therapy in diabetes. Copyright © 2013 John Wiley & Sons, Ltd.