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Differential gene expression of the key signalling pathway in para‐carcinoma, carcinoma and relapse human pancreatic cancer
Author(s) -
Chang ZhengYan,
Sun Ran,
Ma YuShui,
Fu Da,
Lai XiaoLong,
Li YuSheng,
Wang XingHong,
Zhang XiaoPing,
Lv ZhongWei,
Cong XianLing,
Li WenPing
Publication year - 2014
Publication title -
cell biochemistry and function
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.933
H-Index - 61
eISSN - 1099-0844
pISSN - 0263-6484
DOI - 10.1002/cbf.3009
Subject(s) - carcinogenesis , pancreatic cancer , kegg , cancer research , microarray , cancer , hedgehog signaling pathway , biology , dna microarray , gene , carcinoma , gene expression , gene expression profiling , bioinformatics , gene ontology , genetics
Pancreatic cancer (PC) has a high rate of mortality and a poorly understood mechanism of progression. Investigation of the molecular mechanism of PC and exploration of the specific markers for early diagnosis and specific targets of therapy are key points to prevent and treat PC effectively and to improve their prognosis. In our study, expression profiles experiment of para‐carcinoma, carcinoma and relapse human PC was performed using Agilent human whole genomic oligonucleotide microarrays with 45 000 probes. Differentially expressed genes related with PC were screened and analysed further by Gene Ontology term analysis and Kyoto encyclopaedia of genes and genomes pathway analysis. Our results showed that there were 3853 differentially expressed genes associated with pancreatic carcinogenesis and relapse. In addition, our study found that PC was related to the Jak–STAT signalling pathway, PPAR signalling pathway and Calcium signalling pathway, indicating their potential roles in pancreatic carcinogenesis and progress. Copyright © 2013 John Wiley & Sons, Ltd.