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Inverse correlation of intracellular calcium and cyclic AMP levels in renal cell carcinoma
Author(s) -
Sharma Ujjawal,
Singh Shrawan Kumar,
Rajendra Prasad
Publication year - 2012
Publication title -
cell biochemistry and function
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.933
H-Index - 61
eISSN - 1099-0844
pISSN - 0263-6484
DOI - 10.1002/cbf.2913
Subject(s) - renal cell carcinoma , intracellular , calcium , calcium in biology , pathogenesis , endocrinology , second messenger system , medicine , parenchyma , renal parenchyma , kidney , carcinoma , chemistry , pathology , biochemistry
Renal cell carcinoma (RCC) is the most common renal tumour in adults. Altered levels of secondary messengers, that is, intracellular calcium and cyclic AMP (cAMP), have been implicated in the pathogenesis of various malignancies. In the present study, we measured levels of intracellular calcium and cAMP in RCC. The intracellular calcium level was significantly reduced, whereas the cAMP level was significantly augmented in RCC as compared with adjacent grossly normal renal parenchyma. Copyright © 2012 John Wiley & Sons, Ltd.