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Effects of choline and ethanolamine on the synthesis and breakdown of the inositol phospholipid (PI) system in Tetrahymena
Author(s) -
Kovács P.,
Csaba G.
Publication year - 1995
Publication title -
cell biochemistry and function
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.933
H-Index - 61
eISSN - 1099-0844
pISSN - 0263-6484
DOI - 10.1002/cbf.290130111
Subject(s) - inositol , tetrahymena , phospholipid , second messenger system , tetrahymena pyriformis , pi , ethanolamine , chemistry , biochemistry , choline , biology , enzyme , receptor , membrane
Lower concentrations of choline chloride and ethanolamine (10 −3 M ; 10 −5 M ) increased phosphatidyl inositol (PI), phosphatidyl inositol monophosphate (PIP) and phosphatidyl inositol bisphosphate (PIP 2 ) level of Tetrahymena , while higher concentrations (10 −2 M ) decreased them. These two substances also influenced, however in a less obvious way, the transformation of inositol phospholipids. The experiments draw attention to the sensitivity of the precursors of the second messenger system at a phylogenetically low level.