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Glucocorticoid‐induced changes in liver: Effect of dexamethasone administration on DNA topoisomerase I and II activities and distribution of histone H1 subtypes
Author(s) -
Goodlad George A. J.,
Clark Catherine M.
Publication year - 1994
Publication title -
cell biochemistry and function
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.933
H-Index - 61
eISSN - 1099-0844
pISSN - 0263-6484
DOI - 10.1002/cbf.290120404
Subject(s) - topoisomerase , histone , dexamethasone , glucocorticoid , dna , transcription (linguistics) , biology , acetylation , dna replication , microbiology and biotechnology , endocrinology , medicine , gene , biochemistry , linguistics , philosophy
The activities of DNA topoisomerase I and II and the relative proportions of the histone H1 subtypes were investigated in rat liver which was undergoing hypertrophy and exhibiting increased transcriptional activity following the administration of dexamethasone. There was a rise in the level of activity of DNA topoisomerase I and a slight fall in that of DNA topoisomerase II. The relative proportions of the H1 subtypes were altered due to a preferential increase in H1.1. The results are discussed in relation to the effect of glucocorticoids on the transcription and replication of hepatic DNA.