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Reduced 4‐hydroxynonenal degradation in hearts of spontaneously hypertensive rats during normoxia and postischemic reperfusion
Author(s) -
Grune T.,
Schönheit K.,
Blasig I.,
Siems W.
Publication year - 1994
Publication title -
cell biochemistry and function
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.933
H-Index - 61
eISSN - 1099-0844
pISSN - 0263-6484
DOI - 10.1002/cbf.290120210
Subject(s) - 4 hydroxynonenal , lipid peroxidation , medicine , endocrinology , chemistry , ischemia , muscle hypertrophy , antioxidant , biochemistry
4‐Hydroxynonenal (HNE) degradation was investigated in isolated perfused rat hearts of the WKY and SHR strains before and after ischemia. HNE (10 μmoles l −1 ) were infused and the concentration of HNE in the effluent was determined. The rate of initial consumption was about 50 nmoles min −1 g −1 wet weight in hearts of both the WKY and SHR rats. In the WKY rat hearts, this rate of HNE degradation did not change during several minutes of HNE infusion and also remained constant during postischemic reperfusion. In the hearts of the SHR rats the HNE degradation rate declined within 5 min to 25 nmoles min −1 g −1 wet weight. Also during postischemic reperfusion, there was a lower HNE degradation rate in the SHR rat hearts than in the WKY rat hearts. The influence of hypertrophy on the rate of HNE degradation is discussed. It is suggested that the low degradation of the cytotoxic lipid peroxidation product, HNE, in hypertrophic hearts may contribute to reduced antioxidant defence in those hearts.