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Extracellular calcium modulates proliferation of factor dependent hemopoietic cells
Author(s) -
Martínez Jorge,
Santibañez Juan F.
Publication year - 1993
Publication title -
cell biochemistry and function
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.933
H-Index - 61
eISSN - 1099-0844
pISSN - 0263-6484
DOI - 10.1002/cbf.290110205
Subject(s) - extracellular , calcium , microbiology and biotechnology , haematopoiesis , chemistry , cell culture , growth factor , cell growth , bone marrow , t type calcium channel , calcium channel , biology , biophysics , stem cell , biochemistry , immunology , receptor , genetics , organic chemistry
Blockade of the calcium channel inhibited, in a dose‐dependent manner, the proliferation of the IL‐3 dependent FDCP‐1 cell line and normal murine bone marrow cells. Similar results were obtained by lowering the amount of extracellular calcium using specific chelators or a calcium‐free medium. These results suggest that factor‐dependent cell proliferation is highly sensitive to fluctuations in the concentration of extracellular calcium.