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Effect of streptozotocin‐induced diabetes on the handling of phosphate by the rat small intestine
Author(s) -
AlSawan S.,
Skillen A. W.
Publication year - 1992
Publication title -
cell biochemistry and function
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.933
H-Index - 61
eISSN - 1099-0844
pISSN - 0263-6484
DOI - 10.1002/cbf.290100409
Subject(s) - streptozotocin , brush border , diabetes mellitus , small intestine , medicine , endocrinology , phosphate , alkaline phosphatase , chemistry , choline , membrane , enzyme , biochemistry , biology , vesicle
The effect of chemically‐induced diabetes on the handling of phosphate (Pi) by rat jejunal enterocytes has been investigated in the presence of a Na‐ or a choline‐gradient. Pi uptake was significantly increased in both gradients. The Pi efflux rate constants for enterocytes from diabetic rats were similar to those of control rats. The effect of diabetes on both the protein and alkaline phosphatase isoenzymes of the rat small intestinal brush‐border membranes was examined using SDS‐PAGE. The patterns given by membranes from rats 14 days after the induction of diabetes were no different from those of controls.