Premium
Mitoxantrone toxicity on ehrlich ascites tumour cells: Inhibition of the transplasma membrane redox activity
Author(s) -
Medina Miguel Angel,
Luque Pilar,
De Castro Ignacio NÚñez
Publication year - 1991
Publication title -
cell biochemistry and function
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.933
H-Index - 61
eISSN - 1099-0844
pISSN - 0263-6484
DOI - 10.1002/cbf.290090205
Subject(s) - mitoxantrone , toxicity , ascites , ehrlich ascites , chemistry , redox , pharmacology , cancer research , medicine , chemotherapy , tumor cells , organic chemistry
This study focused on the potent cytotoxic effect that mitoxantrone produces on Ehrlich ascites tumour cells. Host mice treated with mitoxantrone showed a life span three times higher than control non‐treated host mice. Mitoxantrone also showed a potent cytotoxic effect on Ehrlich cells incubated in vitro for only a few hours. Studies on the effect of mitoxantrone on a plasma membrane redox system showed that mitoxantrone inhibits this activity, which is apparently related to cell proliferation.