Premium
Fructose‐1, 6‐diphosphate as an in vitro and in vivo anti‐alcohol agent in the rat
Author(s) -
Galzigna L.,
Bianchi M.,
Rizzoli V.,
Scuri R.,
Giannetti P.,
Paesano A.
Publication year - 1990
Publication title -
cell biochemistry and function
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.933
H-Index - 61
eISSN - 1099-0844
pISSN - 0263-6484
DOI - 10.1002/cbf.290080107
Subject(s) - ethanol , in vivo , chemistry , in vitro , fructose , alcohol , pharmacology , efflux , diuresis , endocrinology , medicine , biochemistry , biology , microbiology and biotechnology , renal function
Abstract Fructose‐1, 6‐diphosphate (FDP) decreases the effect of ethanol on Ca ++ entry and inhibits the ethanol‐stimulated phosphate efflux in rat heart slices. FDP also inhibits the ethanol‐stimulated [ 36 Cl − ]‐uptake by rat brain microvesicles and affects the isolated GABA‐receptor in a way opposite to that of ethanol. The in vivo effects of FDP include a dose‐dependent decrease in ethanol‐induced gastric ulcers and a decrease in the serum transaminase levels raised by chronic ethanol administration. Other central actions of ethanol such as diuresis, narcosis, dependence and withdrawal symptoms are also counteracted by FDP.