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Dual inhibitory effect of bredinin
Author(s) -
Kusumi T.,
Tsuda M.,
Katusunuma T.,
Yamamura M.
Publication year - 1989
Publication title -
cell biochemistry and function
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.933
H-Index - 61
eISSN - 1099-0844
pISSN - 0263-6484
DOI - 10.1002/cbf.290070308
Subject(s) - enzyme , inhibitory postsynaptic potential , chemistry , dehydrogenase , biochemistry , cell culture , phosphate , growth inhibition , glucose 6 phosphate dehydrogenase , cell growth , microbiology and biotechnology , biology , genetics , neuroscience
Bredinin inhibition of cell growth was investigated in the mouse lymphoma cell line L5178Y. Bredinin caused the accumulation of IMP and the reduction of XMP. It was converted to the 5′‐phosphate within the cells. Bredinin 5′‐phosphate but not bredinin competitively inhibited both IMP dehydrogenase and GMP synthetase. Thus the inhibition of cell growth is probably due to bredinin 5′‐phosphate, which inhibits the consecutive enzyme reactions IMP dehydrogenase and GMP synthetase. These inhibitions result in the accumulation of IMP and the reduction of XMP.