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Purine and pyridine nucleotides in rabbit red blood cells of different maturity
Author(s) -
Werner Andreas,
Siems Werner,
Gerber Gerhard
Publication year - 1988
Publication title -
cell biochemistry and function
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.933
H-Index - 61
eISSN - 1099-0844
pISSN - 0263-6484
DOI - 10.1002/cbf.290060406
Subject(s) - reticulocytosis , purine , nucleotide , biochemistry , oxidative phosphorylation , chemistry , red blood cell , purine metabolism , glycolysis , biology , metabolism , medicine , enzyme , gene , anemia
Using reversed‐phase high‐performance liquid chromatography purine nucleotides, nucleosides and nucleobases as well as pyridine nucleotides were determined in extracts of reticulocytes and mature red blood cells of rabbits. The concentrations of almost all compounds measured decrease during the last phase of red blood cell maturation. These changes were interpreted with respect to the loss of mitochondria, accompanied by shifting the energy production from the preferentially oxidative mode to the exclusively glycolytic one and variations in the concentrations of purine compounds in blood plasma during reticulocytosis.