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Immunofluorescent localization of transglutaminase in rat small intestine
Author(s) -
Sharp Gaynor,
Grindley Helen,
Lorand L.,
Peters Timothy J.
Publication year - 1988
Publication title -
cell biochemistry and function
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.933
H-Index - 61
eISSN - 1099-0844
pISSN - 0263-6484
DOI - 10.1002/cbf.290060209
Subject(s) - tissue transglutaminase , brush border , immunofluorescence , cytoplasm , guinea pig , coeliac disease , pathogenesis , antibody , biology , immunoglobulin a , pathology , immunoglobulin g , microbiology and biotechnology , immunology , enzyme , biochemistry , medicine , disease , endocrinology , vesicle , membrane
The distribution of intestinal transglutaminase was investigated by immunofluorescence microscopy using rabbit anti‐guinea pig transglutaminase immunoglobulin. Transglutaminase‐related antigen was demonstrated principally in the cytoplasm of villous core interstitial cells with some activity in the brush border region of the villous epithelial cells. Implications for the pathogenesis of coeliac disease are discussed.