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Subcellular calmodulin distribution in rat liver after CCl 4 poisoning
Author(s) -
Barrera G.,
Parola M.,
Paradisi L.,
Albin L.,
Dianzani M. U.
Publication year - 1987
Publication title -
cell biochemistry and function
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.933
H-Index - 61
eISSN - 1099-0844
pISSN - 0263-6484
DOI - 10.1002/cbf.290050208
Subject(s) - calmodulin , cytosol , intracellular , calcium , microsome , distribution (mathematics) , chemistry , calcium in biology , homeostasis , liver cell , hepatocyte , subcellular localization , calcium metabolism , biochemistry , endocrinology , medicine , biology , enzyme , in vitro , cytoplasm , mathematical analysis , mathematics
Disturbed cellular calcium homeostasis has been observed during CCl 4 poisoning, with an increase in calcium content 1 h after administration. Intracellular increase of calcium may be expected to alter membrane/cytosol distribution of calmodulin (CaM). This paper investigates changes in rat liver subcellular CaM distribution 30 min, 1 h and 2 h after CCl 4 intoxication. The whole liver value remained unchanged, whereas the nuclear fraction increased and the microsomal and cytosolic fraction decreased. This may suggest that CaM is involved in the several liver cell alterations caused by CCl 4 poisoning.