Premium
The effects of acute phosphate depletion on isolated chick kidney tubule cells
Author(s) -
Grahn Michael F.,
Butterworth Peter J.
Publication year - 1986
Publication title -
cell biochemistry and function
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.933
H-Index - 61
eISSN - 1099-0844
pISSN - 0263-6484
DOI - 10.1002/cbf.290040407
Subject(s) - phosphate , parathyroid hormone , chemistry , intracellular , tubule , renal tubule , kidney , hydrolysis , inorganic phosphate , hormone , biochemistry , proximal tubule , endocrinology , medicine , biology , calcium , organic chemistry
Isolated tubule cells from chick kidney respond to a short period of phosphate deprivation with increased phosphate uptake and a resistance to parathyroid hormone. During phosphate depletion a considerable amount of phosphate may be released from the cells, but intracellular inorganic phosphate levels are maintained by the hydrolysis of organic phosphate esters. It is suggested that the concomitant changes in metabolism might act as the signal causing the onset of the changes in phosphate handling associated with phosphate deprivation.