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Is the saccharide component of the insulin receptor involved in hormonal imprinting?
Author(s) -
Kovács P.,
Csaba G.
Publication year - 1986
Publication title -
cell biochemistry and function
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.933
H-Index - 61
eISSN - 1099-0844
pISSN - 0263-6484
DOI - 10.1002/cbf.290040206
Subject(s) - tetrahymena , imprinting (psychology) , hormone , insulin , concanavalin a , receptor , biology , chemistry , lectin , microbiology and biotechnology , biochemistry , endocrinology , gene , in vitro
Hormonal imprinting takes place at the first interaction of a given hormone with the cell (the Tetrahymena in the present case) and accounts for a greater responsiveness to the hormone on re‐exposure(s). The Tetrahymena is able to bind insulin and Concanavalin‐A (Con‐A) as well. Exposure to both ligands—simultaneously or in sequence—enhances the binding of both in the progeny generations. It follows that the lectin, which inhibits insulin binding by direct action, enhances rather than depresses the effect of insulin‐induced imprinting.