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Effect of methylglyoxal on tumour microtubular protein
Author(s) -
Miglietta A.,
Bonelli G.,
Vironda N.,
Gabriel L.
Publication year - 1985
Publication title -
cell biochemistry and function
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.933
H-Index - 61
eISSN - 1099-0844
pISSN - 0263-6484
DOI - 10.1002/cbf.290030104
Subject(s) - methylglyoxal , colchicine , in vivo , microtubule , cell division , biochemistry , chemistry , in vitro , mechanism of action , cell , ehrlich ascites carcinoma , pharmacology , microbiology and biotechnology , biology , enzyme , genetics
Methylglyoxal inhibits cell division, exerting an antiproliferative action on tumour cells. Supernatants from ascites hepatoma cell homogenate, previously incubated with the aldehyde, showed a decrease in colchicine binding activity dependent on methylglyoxal concentration. In contrast, in vivo treatment of tumour‐bearing rats apparently did not cause a significant impairment of microtubular protein, suggesting that the aldehyde interaction with microtubules cannot be considered responsible for its carcinostatic action.