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Behaviour of cyclic nucleotides and Ca 2+ levels in liver tissue of rats poisoned by white phosphorus and trichlorobromomethane
Author(s) -
Paradisi L.,
Panagini C.,
Negro F.,
Parola M.,
Torrielli M. V.
Publication year - 1984
Publication title -
cell biochemistry and function
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.933
H-Index - 61
eISSN - 1099-0844
pISSN - 0263-6484
DOI - 10.1002/cbf.290020211
Subject(s) - white phosphorus , hepatotoxin , phosphorus , cyclic nucleotide , medicine , endocrinology , chemistry , nucleotide , steatosis , liver tissue , necrosis , biology , biochemistry , toxicity , organic chemistry , gene
The content of hepatic cyclic AMP was increased soon after intoxication by white phosphorus. Its level reached a maximum 4 h after poisoning, but in subsequent phases tended to return to normal. In contrast, the cyclic GMP concentration was altered only 24 and 36 h after treatment with the same hepatotoxin. Similar modifications of cAMP and cGMP content were also detected after poisoning by trichlorobromomethane (CBrCl 3 ). As a consequence, an altered cGMP/cAMP ratio was found in both experimental conditions. Further, the modification of cAMP content after white phosphorus was detected prior to liver damage (steatosis and necrosis), while the highest concentration of the cyclic nucleotide in CBrCl 3 ‐poisoned rats was found when fatty liver was already evident. In addition, in phosphorus‐poisoned rats, the hepatic content of Ca 2+ was found to be unmodified during all phases of the intoxication, while after CBrCl 3 a phasic increase of the Ca 2+ level was observed at 4, 24 and 36 h.